Synthesis and Optoelectronic Properties of a Novel Pt(IV)(C∧N∧C)(Cl)2(DMSO) Complex Cyclometalated by Tridentate Diphenylpyridine.

A novel tridentate-cyclometalating Pt(IV) complex, namely, Pt(IV)(C∧N∧C)(Cl)2(DMSO), is initially synthesized through a series of reactions using Pt(II) complexes. The optoelectronic properties of Pt(IV)(C∧N∧C)(Cl)2(DMSO) are fully studied by adequate characterizations.

Effect of otago exercise on falls in patients with osteoarthritis: A protocol for systematic review and meta-analysis.

BACKGROUND: Osteoarthritis (OA) is considered as an established risk factor for falls, while exercise can effectively prevent falls. However, whether otago exercise can prevent falls in OA patients is still controversial. Based on sufficient clinical studies, this study aimed to apply meta-analysis to evaluate the effectiveness of otago exercise on preventing falls in OA patients with. METHODS: PubMed, EMbase, Web of Science and Cochrane Library were searched to collect randomized controlled trial (RCT) of the effect of Otago exercise on falls in OA patients. The search time limit was from the establishment of the database to September 2020. After the 2 researchers independently screened the literature, the data was extracted and the bias risk included in the study was evaluated. Meta-analysis was carried out with RevMan 5.3software. RESULTS: The results of our meta-analysis could be published in peer-reviewed journals. CONCLUSION: This study provided high-quality evidence to support the effect of Otago exercise on falls in OA patients. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/Z5XGV.

Para-Conjugated Dicarboxylates with Extended Aromatic Skeletons as the Highly Advanced Organic Anodes for K-Ion Battery.

A new family of the para-conjugated dicarboxylates embedding in biphenyl skeletons was exploited as the highly advanced organic anodes for K-ion battery. Two members of this family, namely potassium 1,1'-biphenyl-4,4'-dicarboxylate (K2BPDC) and potassium 4,4'-E-stilbenedicarboxylate (K2SBDC), were selectively studied and their detailed redox behaviors in K-ion battery were also clearly unveiled. Both K2BPDC and K2SBDC could exhibit very clear and highly reversible two-electron redox mechanism in K-ion battery, as well as higher potassiation potentials (above 0.3 V vs K+/K) when compared to the inorganic anodes of carbon materials recently reported. Meanwhile, the satisfactory specific and rate capacities could be realized for K2BPDC and K2SBDC. For example, the K2BPDC anode could realize the stable rate capacities of 165/143/135/99 mAh g-1 under the high current densities of 100/200/500/1000 mA g-1, respectively, after its electronic conductivity was improved by mixing a very small amount of graphene. More impressively, the average specific capacities of ∼75 mAh g-1 could be maintained for the K2BPDC anode for 3000 cycles under the high current density of 1 A g-1.

miR­542­3p overexpression is associated with enhanced osteosarcoma cell proliferation and migration ability by targeting Van Gogh­like 2.

Osteosarcoma is the most common histological form of primary bone cancer, which arises from osteoid tissue. It occurs predominantly in infants and adolescents, with an incidence of 4­5 cases/100,000,000. The 5-year survival rate of patients with osteosarcoma has significantly improved over time; however, there remains a significant proportion of patients that respond poorly to chemotherapy. An improved understanding of the pathology of osteosarcoma is required to provide more effective treatment strategies, identify biomarkers and develop novel chemotherapeutic agents. Disturbance in microRNA (miRNA) expression has been identified in osteosarcoma tissues and cell lines; however, the roles of miRNA during osteosarcoma pathogenesis remain to be elucidated. In the present study, the expression levels of eight selected miRNAs were investigated in osteosarcoma tissues and the results revealed that the expression levels of miR­542­3p and miR­542­5p were significantly upregulated and the expression of miR­199­3p was significantly downregulated. Using a dual luciferase assay and western blot analysis, the present study confirmed that Van Gogh­like 2, which is a non­canonical Wnt pathway suppressor, was a target gene of miR­542­3p. Subsequently, the biological function of miR­542­3p in U2OS cells was examined, which revealed that overexpression of miR­542­3p can enhance the cell proliferation and migration ability of U2OS cells. This indicated that miR­542­3p may act as an oncogene in osteosarcoma pathogenesis. The findings of the present study may provide assistance in understanding the development of osteosarcoma and aid in the development of strategies for the diagnosis and treatment of osteosarcoma.

A polymorphism site in the pre­miR­34a coding region reduces miR­34a expression and promotes osteosarcoma cell proliferation and migration.

Osteosarcoma (OS) is the most prevalent primary malignant bone tumor in children and young adults, its complex etiology involving a combination of environmental and genetic factors. MicroRNA (miRNA) is a short, non­coding regulatory RNA molecule that represses gene expression by imperfectly base­pairing to the 3' untranslated region of target mRNAs. Evidence has shown that alterations in the expression of miRNA are involved in the initiation, progression, and metastasis of human cancers. It is believed that miRNAs function both as tumor suppressors and oncogenes during cancer development. In the present study, three tumor-associated miRNAs (miR­21, miR­34a and miR­146a) coding regions were screened in Chinese­Han OS patients. A G>A variation in the pre­miR­34a coding region was found to be associated with higher OS morbidity. By detecting the mature miR­34a expression in cells transfected with pre­miR­34a expression vectors of different genotypes using quantitative polymerase chain reaction, it was demonstrated that the G>A variation reduced miR­34a expression in vitro. This was in accordance with the data collected from tumor tissue and patient serum samples. Subsequently, a dual­luciferase reporter assay and western blot analysis were used to detect the site variation effect on the expression of c­Met, a target gene of miR­34a. The G>A variation downregulated the suppression of c­Met in two OS cell lines. Furthermore, it was found that reduced miR­34a expression decreased the suppression of OS cell proliferation in vitro. In conclusion, the present study established the association between miR­34a and the risk of suffering OS in a Chinese Han population by identifying one functional single nucleotide polymorphism site in pre­miR­34a. These findings may give insight into the mechanism of OS development and create an opportunity to approach the diagnosis and treatment of OS.